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76‐kDa poly(A)—protein is involved in the formation of 48 S initiation complexes
Author(s) -
Schmid Hans-Peter,
Schönfelder Max,
Setyono Buddy,
Köhler Kurt
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)81125-9
Subject(s) - messenger rna , globin , chemistry , biochemistry , microbiology and biotechnology , biology , gene
In erythropoietic mouse cells induced by Friend leukemia virus, ≈50% of non‐polyribosomal globin mRNA is found in 48 S initiation complexes ready to be translated. EDTA releases 15 S globin mRNPs, homologous to polyribosomal globin mRNPs. The 76‐kDa poly(A)—protein is one of its main protein components. The other 50% of non‐polyribosomal message can be separated as 20 S ‘free’ mRNPs. Its protein composition is different, especially the 76‐kDa protein is lacking. The role of this protein is discussed.