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Regulation of human placental deoxyguanosine kinase by nucleotides
Author(s) -
Yamada Yasukazu,
Goto Haruko,
Ogasawara Nobuaki
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)81114-4
Subject(s) - deoxyguanosine , activator (genetics) , nucleotide , chemistry , human placenta , biochemistry , enzyme , placenta , dna , biology , fetus , gene , genetics , pregnancy
The activity of deoxyguanosine kinase purified from human placenta was regulated by various nucleotides. dTTP, an activator, only increased the V max value of the enzyme. The feedback inhibition by dGTP, dGDP and dGMP were competitive with respect to deoxyguanosine. Both the activation by dTTP and the inhibition by dGTP were reversible.