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Characteristics of redox‐linked proton ejection in cytochrome c oxidase reconstituted in phospholipid vesicles
Author(s) -
Papa S.,
Lorusso M.,
Capitanio N.,
De Nitto E.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)81106-5
Subject(s) - redox , cytochrome c oxidase , chemistry , vesicle , proton , oxidase test , biophysics , biochemistry , enzyme , inorganic chemistry , biology , physics , membrane , quantum mechanics
Experimental observations reveal a number of characteristics of the redox‐linked proton ejection from cytochrome c oxidase vesicles, which apparently cannot be explained by a proton pumping activity of the oxidase. These observations seem, on the other hand, to provide useful elements for alternative explanation(s) of the proton ejection. It is proposed here that the process is scalar and not vectorial and can derive from redox‐linked rupture of protonated salt‐bridges in the oxidase‐lipid complex.