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Stimulation of an exocytotic event, the hamster sperm acrosome reaction, by cis ‐unsaturated fatty acids
Author(s) -
Meizel Stanley,
Turner Kenneth O.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)81032-1
Subject(s) - acrosome reaction , hamster , chemistry , sperm , arachidonic acid , docosahexaenoic acid , biochemistry , unsaturated fatty acid , fatty acid , biology , in vitro , polyunsaturated fatty acid , botany , endocrinology , enzyme
This cis ‐unsaturated fatty acids oleic, arachidonic and cis ‐vaccenic stimulated the hamster sperm acrosome reaction in vitro (an exocytotic event which occurs in the sperm head and which is essential for fertilization). The trans ‐isomers of oleic and vaccenic acids did not stimulate the acrosome reaction, nor did the cis ‐unsaturated fatty acids petroselenic and docosahexaenoic or the saturated fatty acids lauric, myristic or stearic. This is the first report of a stimulatory effect of cis ‐unsaturated fatty acids on an exocytic event in an intact viable cell.