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Evidence that the α 2 HS glycoprotein receptor and the Epstein‐Barr virus nuclear antigen (EBNA) are identical
Author(s) -
Lewis J.G.,
André C.M.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)81030-8
Subject(s) - glycoprotein , antigen , receptor , virus , biology , microbiology and biotechnology , alpha (finance) , epstein–barr virus , virology , immunology , biochemistry , medicine , construct validity , nursing , patient satisfaction
Evidence is presented which suggests that the α 2 HS glycoprotein (α 2 HS) receptor on lymphocytes transformed by Epstein—Barr virus (EBV) and the EBV‐determined nuclear antigen (EBNA) are immunologically related, and may be identical. Western blotting, using both anti‐EBNA and anti‐α 2 HS receptor serum identified a similar M r 48 000 component in labelled detergent‐solubilized transformed cell supernatants. The M r 48 000 component recognized by anti‐EBNA serum had a pI between 7–8, similar to that reported for the α 2 HS receptor.