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Characteristics of platelet aggregation induced by the monoclonal antibody ALB 6 (acute lymphoblastic leukemia antigen p 24)
Author(s) -
Boucheix Claude,
Soria Claudine,
Mirshahi Massoud,
Soria Jeannette,
Perrot Jean-Yves,
Fournier Noëlle,
Billard Martine,
Rosenfeld Claude
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)81027-8
Subject(s) - monoclonal antibody , antigen , lymphoblastic leukemia , antibody , medicine , platelet , leukemia , immunology , monoclonal , acute lymphocytic leukemia , microbiology and biotechnology , cancer research , biology
The leukemia‐associated cell surface antigen p 24 is found on normal platelets as well as on Bernard Soulier syndrome and thrombasthenia type I platelets. ALB 6 IgG (a monoclonal antibody against p 24) induces the aggregation of platelets from normal donors but not from thrombasthenia. In contrast, ALB 6 Fab inhibits platelet aggregation induced by collagen, ADP, thrombin, ionophore A 23187 and ALB 6 IgG. The results suggest that ALB 6 interferes with a mechanism common to all aggregation pathways; the possible mechanisms are discussed.