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Co‐operation between metastatic tumor cells and macrophages in the degradation of basement membrane (type IV) collagen
Author(s) -
Henry Nicole,
Eeckhout Yves,
van Lamsweerde Anne-Louise,
Vaes Gilbert
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)81017-5
Subject(s) - basement membrane , type iv collagen , chemistry , degradation (telecommunications) , membrane , biophysics , metastatic tumor , cancer research , microbiology and biotechnology , pathology , metastasis , medicine , biochemistry , biology , extracellular matrix , laminin , cancer , computer science , telecommunications
The co‐culture of mouse peritoneal macrophages and Lewis lung carcinoma cells induces the relase of a metal‐dependent type IV collagen‐degrading proteinase which is not produced in detactable amounts by either cell type cultivated alone. Conditioned media of the co‐cultures degrade both pepsin‐extracted type IV collagen from human placenta and mouse type IV procollagen. Thus macrophages can interact with tumor cells to degrade basement membrane type IV collagen: this might be of importance to allow cancer invasion and metastasis.