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Myosin isozyme changes in the heart following constriction of the ascending aorta of a 25‐day old rat
Author(s) -
Bugaisky Lawrence B.,
Siegel Elisabeth,
Whalen Robert G.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)81014-x
Subject(s) - ascending aorta , isozyme , constriction , aorta , medicine , muscle hypertrophy , myosin , anatomy , cardiology , chemistry , biology , biochemistry , enzyme
When a constricting band is placed around the ascending aorta of young (25‐day old) rats, all chambers of the heart eventually produce hypertrophy. Both the left and right ventricles show strong shifts toward an isozyme pattern in which V3 is predominant, similar to that seen in models were hypertrophy is induced in adult rats. The hypertrophied atria however, show no detectable change in the native myosin isozymes or the light chain subunits.