Premium
Stimulation of glycogenolysis in hepatocytes by angiotensin II may involve both calcium release and calcium influx
Author(s) -
DeWitt Linda M.,
Putney James W.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80978-8
Subject(s) - glycogenolysis , extracellular , stimulation , calcium , chemistry , intracellular , endocrinology , angiotensin ii , medicine , hepatocyte , calcium in biology , guinea pig , biophysics , biochemistry , biology , glycogen , receptor , in vitro , organic chemistry
The stimulation of [ 3 H]glucose release (a measure of glycogenolysis) from isolated guinea pig hepatocytes by Ca‐mobilizing agonists can be resolved into two phases. The initial transient phase is independent of extracellular Ca, and is probably a result of Ca released from an intracellular pool. The second phase occurs only in the presence of extracellular Ca, which suggests that Ca‐influx is also involved in the mechanism of Ca‐mobilization by these agents in the guinea pig hepatocyte.