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The effect of dichloroacetate and hydroxypyruvate on the entry of 14 C from [1‐ 14 C]alanine into urea in rat hepatocytes
Author(s) -
Hems Reginald
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80977-6
Subject(s) - urea , chemistry , alanine , metabolism , biochemistry , amino acid
Entry of metabolic 14 CO 2 into urea is shown to be decreased by dichloroacetate although the production of 14 CO 2 is stimulated 2‐fold. Hydroxypyruvate, a product of dichloroacetate metabolism, increases the incorporation of metabolic 14 CO 2 into urea. It is proposed that these effects result from changes in the cytoplasmic‐mitochondrial pH gradient.