Premium
Separation of Fe +3 from transferrin in endocytosis
Author(s) -
Rao K.,
van Renswoude J.,
Kempf C.,
Klausner R.D.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80969-7
Subject(s) - endocytosis , transferrin , internalization , transferrin receptor , intracellular , monensin , chemistry , biophysics , cell , microbiology and biotechnology , biochemistry , biology
NH 4 Cl and monensin, two agents which neutralize intracellular acidic compartments, block the segregation of iron from transferrin after endocytosis, while neither of these reagents affects internalization of diferric transferrin into the cell. In conclusion the molecular separation of iron from transferrin inside the cell requires a non‐lysosomal acidic compartment