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Acetyl glyceryl ether phosphorylcholine (platelet‐activating factor) mediates heightened metabolic activity in macrophages
Author(s) -
Hartung Hans-Peter
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80968-5
Subject(s) - phosphorylcholine , platelet activating factor , mediator , chemistry , eicosanoid , platelet , lipid signaling , biochemistry , ether , phospholipid , microbiology and biotechnology , biology , immunology , receptor , enzyme , arachidonic acid , organic chemistry , membrane
The phospholipid mediator AGEPC (acetyl glyceryl ether phosphorylcholine) was examined for its effects on guinea pig peritoneal macrophages. At a concentration of 10 −9 ‐10 −6 M, AGEPC evoked release of prostaglandin E (PGE) and thromboxane B 2 (TXB 2 ) from albumin‐elicited macrophages. It also triggerd generation of O − 2 by Corynebacterium parvum ‐induced cells. Moreover, it caused augmented spreading of macrophages. The calmodulin antagonis W‐7 attenuated AGEPC‐mediated O − 2 production and cell spreading whereas prostanoid synthesis was enhanced. These novel actions of AGEPC on the major cellular component of the inflammatory process attest to its role as a potent mediator of immunoinflammatory responses.