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Calcium exerts an indirect effect on ATP‐dependent proteolysis of rat liver mitochondria
Author(s) -
Rapoport S.,
Dubiel W.,
Müller M.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80952-1
Subject(s) - proteolysis , mitochondrion , chemistry , calcium , biochemistry , cytosol , inner mitochondrial membrane , biophysics , lanthanum , microbiology and biotechnology , enzyme , biology , inorganic chemistry , organic chemistry
The ATP‐dependent proteolysis of rat liver mitochondria prepared in electrolyte‐poor sucrose media requires the presence of Ca 2+ . Lanthanum, an inhibitor of Ca 2+ uptake, inhibits the proteolysis. In contrast, proteolysis of mitochondria prepared in a salt medium does not require Ca 2+ , nor is it inhibited by lanthanum. It is concluded that Ca a+ exerts its effect in an indirect manner, by causing swelling and thereby increasing the accessibility of the membrane proteins of the inner mitochondrial membrane.