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Age‐related changes in different steps of protein synthesis of liver and kidney of rats
Author(s) -
Gabius Hans-Joachim,
Engelhardt Reinhild,
Deerberg Friedrich,
Cramer Friedrich
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80948-x
Subject(s) - protein biosynthesis , ribosome , kidney , ageing , chromosomal translocation , chemistry , biochemistry , biology , medicine , endocrinology , microbiology and biotechnology , rna , gene
Protein synthesis in cell‐free systems of rat liver and kidney decreases markedly with age. Examination of activity changes of the different steps revealed for both types of organs that reduced binding of aminoacyl‐tRNA to ribosomes and reduced peptidyl transfer might be of major importance for the decrease in overall protein synthesis whereas ageing has only little effect on translocation as well as on initiation and termination.