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Interaction of neuroleptic drugs with a synthetic calcium‐binding peptide analog of site III of rabbit skeletal troponin C
Author(s) -
Reid Ronald E.,
Gariépy Jean,
Hodges Robert S.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80875-8
Subject(s) - trifluoperazine , promethazine , chlorpromazine , chemistry , calcium , troponin c , haloperidol , fluphenazine , peptide , pharmacology , phenothiazine , binding site , troponin i , stereochemistry , calmodulin , biophysics , biochemistry , endocrinology , medicine , dopamine , biology , organic chemistry , myocardial infarction
The effects of nine drugs on the CD spectra of a synthetic calcium binding analog of site III or rabbit skeletal troponin C, can generally be divided into 3 groups: (1) that consisting of haloperidol, benperidol, molindone and promethazine, had no effect on the CD spectrum or calcium sensitivity of the apopeptide; (2) that composed of structurally rigid thioxanthenes, induced CD‐detectable structural change in the apopeptide but prevented Ca 2+ ‐induced structural change; (3) that consisting of chlorpromazine, trifluoperazine and fluphenazine, induced structural change in the peptide but had no effect on the Ca 2+ ‐induced structural change.