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Effect of sodium butyrate on the stimulation of casein gene expression by prolactin
Author(s) -
Martel Paule,
Houdebine Louis-Marie,
Teyssot Bertrand
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80874-6
Subject(s) - prolactin , sodium butyrate , casein , stimulation , butyrate , chemistry , sodium , transcription (linguistics) , gene expression , medicine , messenger rna , endocrinology , biochemistry , biology , gene , hormone , linguistics , philosophy , organic chemistry , fermentation
Sodium butyrate, but not isobutyrate, inhibits prolactin action on the induction of casein synthesis and casein mRNA accumulation in rabbit mammary explants. Sodium butyrate specifically prevents the generation of the prolactin relay which can be released from isolated membranes incubated with prolactin and which stimulates directly casein gene transcription when added to isolated mammary nuclei. This indicates that sodium butyrate exerts its inhibitory action essentially at the membrane level.