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A multifunctional calmodulin‐dependent protein kinase
Author(s) -
McGuinness Teresa L.,
Lai Yvonne,
Greengard Paul,
Woodgett James R.,
Cohen Philip
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80846-1
Subject(s) - calmodulin , biochemistry , protein kinase a , mitogen activated protein kinase kinase , synapsin i , map2k7 , kinase , proteolysis , chemistry , biology , enzyme , cyclin dependent kinase 2 , vesicle , membrane , synaptic vesicle
Calmodulin‐dependent glycogen synthase kinase isolated from skeletal muscle and synapsin I kinase II isolated from brain have several properties that are very similar. These properties include: substrate and site‐specificities, immunological cross‐reactivity, and phosphopeptide maps following limited proteolysis. Both enzymes phosphorylate a wide variety of substrate proteins. The two kinases may represent different isozymes of a multifunctional calmodulin‐dependent protein kinase that mediates many of the actions of Ca 2+ in various tissues. Therefore, we propose the name ‘calmodulin‐dependent multi‐protein kinase’ for this broad specificity enzyme.