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Cytosol Mg 2+ modulates Ca 2+ ionophore induced secretion from rabbit neutrophils
Author(s) -
Di Virgilio F.,
Gomperts B.D.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80843-6
Subject(s) - ionophore , cytosol , secretion , chemistry , calcium , biophysics , rabbit (cipher) , isotopes of calcium , radiochemistry , biochemistry , biology , enzyme , organic chemistry , statistics , mathematics
The influence of extracellular Mg 2+ on Ca 2+ ionophore (A23187 and ionomycin) induced secretion and changes in the cytosol pH of rabbit neutrophils suspended in Ca 2+ ‐free buffer has been investigated. While extracellular Ca 2+ is obligatory for ionomycin induced secretion, we have defined conditions under which A23187 can induce secretion in Ca 2+ ‐free media. The different behaviour of these two Ca 2+ ionophores is discussed on the basis of their different counter cation specificities.