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Complete amino acid sequence of human T‐cell leukemia virus structural protein p15
Author(s) -
Copeland Terry D.,
Oroszlan Stephen,
Kalyanaraman V.S.,
Sarngadharan M.G.,
Gallo Robert C.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80793-5
Subject(s) - edman degradation , amino acid , peptide sequence , bovine leukemia virus , biochemistry , nucleic acid , protein primary structure , microbiology and biotechnology , leukemia , biology , chemistry , virus , virology , gene , genetics
The complete amino acid sequence of human T‐cell leukemia virus (HTLV) structural protein p15 has been determined. The intact protein and peptides generated by enzymatic digestion and acid cleavage were purified by reversed‐phase liquid chromatography and subjected to semi‐automated Edman degradation. HTLV p15 is a basic linear polypeptide composed of 85 amino acids with M r 9458. The primary structure indicates that HTLV p15 is homologous to the nucleic acid binding proteins of other type‐C retroviruses and especially related to bovine leukemia virus p12.