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Heterogeneity of α 2u ‐globulin gene products in different translational systems, plasma and urine
Author(s) -
Mertens Bea,
Vandoren Gaby,
Opdenakker Ghislain,
Volckaert Guido,
Verhoeven Guido
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80775-3
Subject(s) - globulin , heterologous , urine , reticulocyte , messenger rna , biology , gene , alpha globulin , xenopus , chemistry , endocrinology , biochemistry
α 2u ‐Globulin, an androgen dependent rat urinary protein, displays considerable microheterogeneity. To explore whether this microheterogeneity of α 2u ‐globulin in male rat urine is related to the heterogeneity at the level of the genes encoding this protein, or whether it is due to post‐translational processing we studied the α 2u ‐globulin mRNA translation products in rabbit reticulocyte and Xenopus oocytes. Comparison of the α 2u ‐globulin species produced in these two heterologous systems with those observed in plasma and urine indicates that the heterogeneity of this protein in urine is mainly due to heterogeneity at the level of the corresponding mRNAs.