Premium
Regulation of mRNA levels for microtubule proteins during nerve regeneration
Author(s) -
Neumann D.,
Scherson T.,
Ginzburg I.,
Littauer U.Z.,
Schwartz M.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80770-4
Subject(s) - tubulin , regeneration (biology) , microtubule , microbiology and biotechnology , in vivo , messenger rna , biology , retina , protein biosynthesis , chemistry , biochemistry , neuroscience , genetics , gene
The molecular regulation of tubulin synthesis was investigated in the regenerating goldfish retina. Previous in vivo studies pointed to an increase in tubulin synthesis in the retina during regeneration of the injured goldfish optic nerve. Using labeled cDNA probes, we showed that this increase occurs as a result of enhanced tubulin mRNA levels. Analysis of labeled in vivo products revealed enhanced β 2 ‐tubulin synthesis accompanied by an increase in the level of the low‐ M r microtubule‐associated proteins identified as TAU factors. The results are discussed with respect to the possible involvement of these proteins in the process of nerve regeneration.