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The nature of diene conjugation in human serum, bile and duodenal juice
Author(s) -
Cawood P.,
Wickens D.G.,
Iversen S.A.,
Braganza J.M.,
Dormandy T.L.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80763-7
Subject(s) - diene , conjugated diene , chemistry , in vivo , conjugated system , fatty acid , biochemistry , lipid peroxidation , in vitro , organic chemistry , biology , antioxidant , natural rubber , microbiology and biotechnology , polymer , monomer
Diene‐conjugated lipids have been located by HPLC in serum, bile and duodenal juice. Whether esterified or not the same predominant fatty acid is responsible for most of the diene conjugation in all of these biological fluids. Initial attempts to generate this fatty acid in pure lipid by classical lipid peroxidation in vitro were unsuccessful. Ultraviolet irradiation of free fatty acids in the presence of protein produced diene‐conjugated lipids similar to those found in vivo. The predominant diene‐conjugated fatty acid in vivo is an isomerised C18:2 compound.