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Preferential enhancement of myoblast differentiation by insulin‐like growth factors (IGF I and IGF II) in primary cultures of chicken embryonic cells
Author(s) -
Schmid Ch.,
Steiner Th.,
Froesch E.R.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80742-x
Subject(s) - insulin , myocyte , embryonic stem cell , medicine , endocrinology , embryo , insulin like growth factor , cell culture , somatomedin , biology , growth factor , microbiology and biotechnology , cell fusion , cell growth , chemistry , cell , biochemistry , growth hormone , receptor , hormone , gene , genetics
Cells prepared from the body walls of chicken embryos were plated in the absence of serum. Insulin‐like growth factors (IGFs) barely stimulated cell replication, but preferentially enhanced the differentiation of muscle cells. Myoblast fusion was favoured in the presence of IGF (or insulin). Concomitantly, acetylcholinesterase activity increased. IGF I and IGF II were equipotent and active in low physiological concentrations, in contrast to insulin, which was known for a long time to exert such effects at pharmacological concentrations.