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[4,4′‐D‐Diaminopropionic acid]gramicidin S: a synthetic gramicidin S analog with antimicrobial activity against Gram‐negative bacteria
Author(s) -
Ando Shoji,
Aoyagi Haruhiko,
Shinagawa Susumi,
Nishino Norikazu,
Waki Michinori,
Keto Tetsuo,
Izumiya Nobuo
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80736-4
Subject(s) - gramicidin s , gramicidin , antimicrobial , bacteria , escherichia coli , gram negative bacteria , gram positive bacteria , chemistry , phenylalanine , microbiology and biotechnology , staphylococcus aureus , biochemistry , stereochemistry , biology , amino acid , membrane , genetics , gene
Gramicidin S is especially active against Gram‐positive bacteria; e.g., Staphylococcus aureus . An analog, [4,4′‐D‐diaminopropionic acid]gramicidin S, which contains D‐diaminopropionic acid residues instead of D‐phenylalanine residues, has been synthesized. This analog is active against some of the Gram‐negative bacteria; e.g., Escherichia coli and Salmonella typhosa . Activities of several related analogs are discussed.