Premium
Histone gene expression in Physarum polycephalum 2
Author(s) -
Kelly P.M.,
Schofield P.N.,
Walker I.O.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80734-0
Subject(s) - physarum polycephalum , histone , physarum , dna synthesis , dna , dna replication , gene , protein biosynthesis , gene expression , biology , microbiology and biotechnology , chemistry , biochemistry
The addition of hydroxyurea to synchronously growing macroplasmodia of the slime mould, Physarum polycephalum , inhibited DNA synthesis by up to 90%. Histone protein synthesis was inhibited to the same extent. The synthesis of other nuclear proteins was not inhibited even though total RNA synthesis was inhibited. The results suggest that histone synthesis and DNA replication are tightly coupled.