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Gene duplication in bovine brain myelin proteolipid and homology with related proteins
Author(s) -
Laursen Richard A.,
Samiullah Mohammed,
Lees Marjorie B.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80732-7
Subject(s) - proteolipid protein 1 , myelin , gene duplication , homology (biology) , gene , myelin proteolipid protein , biology , protein subunit , biochemistry , genetics , chemistry , microbiology and biotechnology , myelin basic protein , central nervous system , neuroscience
Analysis of the amino acid sequence of bovine brain myelin proteolipid reveals not only extensive internal homology, but also homology with portions of the myelin basic protein, the peripheral nerve myelin protein, P o , and with the small proteolipid subunit of mitochondrial ATP synthase. These results suggest that the myelin proteolipid gene has been constructed from a small number of genetic elements, and that these elements are also found in non‐myelin proteins. Furthermore, the proteolipid appears to have evolved by acquisition of elements from a ‘gene pool’ over a period of time, rather than by a simple duplication mechanism.