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Cyclic AMP, folic acid and pterin‐mediated protein carboxymethylation in cellular slime molds
Author(s) -
van Waarde Aren
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80727-3
Subject(s) - dictyostelium discoideum , pterin , slime mold , chemotaxis , dictyostelium , biochemistry , methylation , mycetozoa , chemistry , extracellular , stimulation , receptor , protein methylation , biology , methyltransferase , enzyme , cofactor , neuroscience , gene
In aggregative cells of Dictyostelium discoideum , extracellular cAMP induces transient methylation of a M r 46 000 protein. Starvation induces a 10–100‐fold increase in the number of cAMP‐receptors, but no change in the amount of the methyl accepting protein. In vegetative amoebae, a temporal increase of methylation of the protein is induced by stimulation with folic acid. Aggregative amoebae of Dictyostelium lacteum also contain a M r 46 000 protein, which is methylated after addition of the attractant monapterin. Therefore, protein carboxymethylation seems to be a general phenomenon during chemotaxis of the cellular slime molds.