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Resistance to apamin of the Ca 2+ ‐activated K + permeability in pancreatic B‐cells
Author(s) -
Lebrun P.,
Atwater I.,
Claret M.,
Malaisse W.J.,
Herchuelz A.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80726-1
Subject(s) - apamin , ionophore , pancreatic islets , islet , medicine , endocrinology , chemistry , biophysics , biology , insulin , calcium , potassium channel
The bee venom neurotoxin apamin failed to affect 86 Rb outflow and insulin release from rat pancreatic islets stimulated by D‐glucose or the Ca 2+ ‐ionophore A23187. Apamin, in contrast to quinine or A23187, also failed to affect bioelectrical activity in mouse islet cells. These findings suggest that, like in erythrocytes, and at variance with the situation found in smooth muscle, liver or neuroblastoma cells, the Ca 2+ ‐activated K + permeability in the pancreatic B‐cell is resistant to apamin.