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Demonstration of a main immunogenic region on acetylcholine receptors from human muscle using monoclonal antibodies to human receptor
Author(s) -
Tzartos Socrates,
Langeberg Lorene,
Hochschwender Susan,
Lindstrom Jon
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80688-7
Subject(s) - acetylcholine receptor , monoclonal antibody , receptor , antibody , microbiology and biotechnology , chemistry , biology , immunology , biochemistry
Eleven cloned hybridomas which secrete antibodies to acetylcholine receptors from human muscle have been prepared. All of these monoclonal antibodies to have the same basic specificity as shown by competition for binding to the main immunogenic region on the receptor, but these antibodies differ in fine specificity as shown by reaction with denatured receptor subunits and interspecies cross‐reaction.