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Effect of lipophilic vitamins on the erythrocyte membrane
Author(s) -
Viti V.,
Cicero R.,
Callari D.,
Guidoni L.,
Billitteri A.,
Sichel G.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80671-1
Subject(s) - microviscosity , bilayer , membrane , chemistry , membrane fluidity , biophysics , lipid bilayer , lipid bilayer fusion , fusion , fluorescence anisotropy , cell fusion , vitamin , biochemistry , cell , biology , linguistics , philosophy
Structural changes induced by the fat‐soluble vitamins A, D 3 , E and K 1 in natural membranes were studied by 31 P NMR and fluorescence anisotropy on erythrocyte ghosts; the occurrence of cell fusion following vitamin addition was detected by optical microscopy of intact cells. Vitamins A, E and K 1 , which produce cell fusion, also induce the formation of configurational phases other than the bilayer and increase, at a different extent for the different vitamins, membrane fluidity. Vitamin D 3 , on the contrary, induces aggregation without fusion, paralleled by bilayer phase stabilization and microviscosity increase. A correlation between fusion phenomena and structural variations in the bilayer organization is therefore suggested.