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The role of lipid peroxidation in the induction of cation transport in rat liver mitochondria
Author(s) -
Marshansky V.N.,
Novgorodov S.A.,
Yaguzhinsky L.S.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80669-3
Subject(s) - oligomycin , lipid peroxidation , cumene hydroperoxide , chemistry , biochemistry , mitochondrion , membrane potential , efflux , oxidative phosphorylation , inner mitochondrial membrane , antioxidant , atpase , enzyme , biophysics , biology , catalysis
Lipid peroxidation in mitochondria induced by Fe 2+ in the presence of ascorbate or by cumene hydroperoxide in the presence of phosphate results in a drop of the membrane potential and in K + efflux. The inhibitors of ATP‐synthetase (oligomycin and dicyclohexylcarbodiimide (DCCD)) are capable of preventing lipid peroxidation, stabilizing the membrane potential and inhibiting potassium efflux. The same effects are observed in the presence of ionol or α‐tocopherol. In contrast to antioxidant protection the effects of oligomycin and DCCD are reversed by the uncoupler (FCCP). The functional link between non‐enzymatic lipid peroxidation, proton conduction through F o component of ATP‐synthetase and induced cation transport is suggested.