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Co‐ordinated regulation of muscle glycolysis and hepatic glucose output in exercise by catecholamines acting via α‐receptors
Author(s) -
Clark Michael G.,
Patten Glen S.,
Filsell Owen H.,
Rattigan Stephen
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80664-4
Subject(s) - endocrinology , medicine , epinephrine , adrenergic receptor , receptor , alpha (finance) , glycolysis , adrenergic , chemistry , carbohydrate metabolism , hindlimb , glucose uptake , metabolism , biology , insulin , construct validity , nursing , patient satisfaction
Recent findings indicate that glucose uptake by contracting hindlimb [Acta Physiol. Scand. (1982) 116, 215‐222] and heart [Biochem. Biophys. Res. Commun. (1982) 108, 124–131] of the rat is stimulated by epinephrine acting through α‐adrenergic mechanisms. Since in exercise hepatic glucose output may be increased markedly by activation of α‐adrenergic receptors and matched by the increase in muscle glucose uptake (maintaining blood glucose levels relatively constant), it is now proposed that a general coordination of glucose metabolism may operate via α‐adrenergic receptor mechanisms. The basis for this proposal is discussed.