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Chick embryo spinal cord neurons synthesize a transferrin‐like myotrophic protein
Author(s) -
Stamatos Cathryn,
Squicciarini Joseph,
Fine Richard E.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80649-8
Subject(s) - ovotransferrin , transferrin , embryo , glycoprotein , spinal cord , chemistry , myogenesis , transferrin receptor , in vitro , microbiology and biotechnology , receptor , biochemistry , biology , neuroscience
Highly enriched cultures of chick embryo spinal cord neurons synthesize and secrete a protein which is immunoprecipitable by anti‐ovotransferrin. Ovotransferrin, an iron‐binding glycoprotein of M r 80 000, is also shown to stimulate in vitro myogenesis of cultured chick embryo myotubes as measured by saturable dose‐dependent increase in acetylcholine receptors. This effect is probably dependent on ovotransferrin's ability to donate iron to the cells. In many respects ovotransferrin is similar to ‘sciatin’, a myotrophic protein isolated from chicken sciatic nerves [Proc. Natl. Acad. Sci. USA (1980) 77, 6922–6925].