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Hemoglobin Kariya [α40 (C5) Lys → Glu]: a new hemoglobin variant with an increased oxygen affinity
Author(s) -
Harano T.,
Harano K.,
Shibata S.,
Ueda S.,
Imai K.,
Tsuneshige A.,
Yamada H.,
Seki M.,
Fukui H.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80636-x
Subject(s) - hemoglobin , heme , chemistry , oxygen , hemoglobin variants , hemeprotein , hemoglobin a , biochemistry , organic chemistry , enzyme
A new abnormal hemoglobin, Hb Kariya [α40 (C5) Lys → Glu], with an amino acid substitution at the α 1 β 2 contact was discovered in a young Japanese man. This variant migrated to the anode faster than Hb A, being nearly the same as Hb I in electrophoretic mobility. It amounted to about 6% of the total hemoglobin of the hemolysate. This hemoglobin showed an increased oxygen affinity, decreased heme—heme interaction and a lowered 2,3‐DPG effect.