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On the relationship between Ca 2+ efflux and membrane damage during t ‐butylhydroperoxide metabolism by liver mitochondria
Author(s) -
Moore Gregory A.,
Jewell Sarah A.,
Bellomo Giorgio,
Orrenius Sten
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80626-7
Subject(s) - mitochondrion , metabolism , efflux , chemistry , membrane , biochemistry , inner mitochondrial membrane , biophysics , biology
The release of Ca 2+ from rat liver mitochondria induced by t ‐butylhydroperoxide metabolism is caused by pyridine nucleotide oxidation and precedes alterations in membrane permeability which appear to result from, rather than cause, Ca 2+ release.