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Isolation of a brain peptide identical to the intestinal PHI (peptide HI)
Author(s) -
Tatemoto Kazuhiko,
Carlquist Mats,
McDonald Thomas J.,
Mutt Viktor
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80617-6
Subject(s) - peptide , peptide sequence , amino acid , biochemistry , isoleucine , chemistry , biology , neurotransmitter , microbiology and biotechnology , stereochemistry , leucine , receptor , gene
The isolation of a brain peptide identical to the intestinal peptide PHI (peptide HI) is described. The peptide was isolated from porcine brain extract using a chemical assay method based on its C‐terminal isoleucine amide structure. The complete amino acid sequence of the peptide was found to be: This sequence is identical to the intestinal peptide thus demonstrating PHI to be a brain‐gut peptide. The role of PHI in the central nervous system as a neurotransmitter or neuromodulator is discussed.