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Hydrogen‐bonded conformation of hyaluronate oligosaccharide fragments in aqueous solution
Author(s) -
Oberholtzer J.C.,
Englander S.W.,
Horwitz A.F.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80601-2
Subject(s) - intramolecular force , hydrogen bond , oligosaccharide , chemistry , aqueous solution , hydrogen , tritium , crystallography , inorganic chemistry , stereochemistry , organic chemistry , molecule , physics , nuclear physics
The hydrogen bonding in hyaluronate oligosaccharide fragments was studied in aqueous solution using hydrogen‐tritium exchange techniques. The data reveal an acetamido hydrogen exchange rate that is 5–6‐fold slower than that seen in model compounds. The magnitude of the slowing is interpreted as reflecting the participation of an acetamido hydrogen in a relatively labile intramolecular hydrogen bond.