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Specific alignment of nucleosomes on DNA correlates with periodic distribution of purine—pyrimidine and pyrimidine—purine dimers
Author(s) -
Zhurkin Victor B.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80598-5
Subject(s) - pyrimidine , purine , dna , nucleosome , stereochemistry , chemistry , sequence (biology) , crystallography , biochemistry , histone , enzyme
Comparison of the X‐ray data and results of conformational analysis reveals the sequence‐dependent helical anisotropy of DNA: purine—pyrimidine (RY) and pyrmidine—purine (YR) dimers prefer bending in the opposite directions. On this basis it is suggested that in the optimal nucleosomal DNA sequence the RY and YR dinucleotides alternate at intervals of 5–6 basepairs. Examination of the cases with the known disposition of nucleosomes confirms this concept.