Premium
Phosphoenolpyruvate shuttle ‐ transport of energy from mitochondria to cytosol
Author(s) -
Drahota Zdeněk,
Rauchová Hana,
Miková Marie,
Kaul Phool,
Bass Arnošt
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80573-0
Subject(s) - cytosol , mitochondrion , phosphoenolpyruvate carboxykinase , chemistry , energy metabolism , biophysics , microbiology and biotechnology , biochemistry , biology , enzyme , endocrinology
Brown‐adipose tissue mitochondria of hamster and rat contain phosphoenolpyruvate carboxykinase (EC 4.1.1.32). In the presence of ketoglutarate and malate, phosphoenolpyruvate is formed and exported forms mitochondria. Phosphoenolpyruvate formation is inhibited by 1,2,3‐benzenetricarboxylate. It is proposed that phosphoenolpyruvate carboxykinase together with pyruvate carboxylase and pyruvate kinase forms a phosphoenolpyruvate shuttle through which energy produced by the Krebs cycle in mitochondria may be exported to cytosol.