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Disappearance of paternal histocompatibility antigens from hybrid mouse blastocyst at the time of implantation
Author(s) -
Leclipteux Thierry,
Remacle José
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80561-4
Subject(s) - histocompatibility , antigen , embryo , blastocyst , fetus , major histocompatibility complex , andrology , immunology , biology , chemistry , microbiology and biotechnology , pregnancy , embryogenesis , medicine , human leukocyte antigen , genetics
Products of the major histocompatibility complex (H‐2) are important in allograph rejection. In view of the close relationship between mother and foetus, we can consider the latter as an allograph which is however not rejected by an immunological reaction. We studied the presence of H‐2 antigens on embryo membranes at the time of implantation, by immunochemical labeling using gold particles coupled with protein A. Results showed that the expression of H‐2 antigens is different before and after implantation. It seems that after implantation, H‐2 antigens disappear from trophoblastic membranes. This could explain the absence of immunological reaction of the mother against the foetus.