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Synthetic peptides mimic subtype specificity of foot‐and‐mouth disease virus
Author(s) -
Clarke B.E.,
Carroll A.R.,
Rowlands D.J.,
Nicholson B.H.,
Houghten R.A.,
Lerner R.A.,
Brown F.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80558-4
Subject(s) - immunogen , foot and mouth disease virus , capsid , virology , virus , biology , antibody , peptide sequence , epitope , amino acid , serology , aphthovirus , serotype , immunology , biochemistry , monoclonal antibody , gene
The major immunogen of foot‐and‐mouth disease virus (FMDV) is located between amino acids 141–160 of the capsid protein VP1. Synthetic peptides corresponding to the major immunogenic region give good neutralising antibody responses and protection in guinea pigs. To define more precisely the immunogenic site of the virus, we have examined serological differences between subtypes of the A serotype using synthetic peptides covering the 141–160 region. We show that these synthetic peptides carry determinants which mimic the subtype specificity of the virus. The correlation between these results and predictive structural models, based on the amino acid sequence, is discussed.