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Two galactose‐specific receptors in the liver with different function
Author(s) -
Roos Peter H.,
Kolb-Bachofen Victoria,
Schlepper-Schäfer Jutta,
Monsigny Michel,
Stockert Richard J.,
Kolb Hubert
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80556-0
Subject(s) - lectin , galactose , asialoglycoprotein receptor , receptor , hepatocyte , chemistry , biochemistry , cell surface receptor , ligand (biochemistry) , macrophage , function (biology) , antiserum , microbiology and biotechnology , antigen , biology , in vitro , immunology
In the rat liver both hepatocytes and macrophages have been shown to express on the surface lectins with similar binding specificity for galactose residues. Functionally the two lectins differ in the uptake of ligands. Whereas the hepatocytes ingest molecules and small particles (< 10 nm), the macrophages take up particles only. Antisera raised against hepatic galactose‐specific receptor failed to react with the macrophage lectin but blocked ligand binding to the hepatocyte lectin. Accordingly, labeling with these antisera and fluorescent protein A occurs with hepatocytes only, indicating either a different antigenic structure or membrane localization of the two lectins.