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The stereochemical configuration of the natural 23,25,26‐trihydroxyvitamin D 3
Author(s) -
Ishizuka Seiichi,
Norman Anthony W.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80521-3
Subject(s) - diastereomer , metabolite , stereochemistry , natural compound , chemistry , natural (archaeology) , biology , biochemistry , biochemical engineering , engineering , paleontology
Four possible diastereoisomers of 23,25,26‐trihydroxyvitamin D 3 were synthesized and compared with the natural metabolite. The 4 synthetic diastereoisomers could be separated into 4 peaks by high‐performance liquid chromatography. The natural 23,25,26‐trihydroxyvitamin D 3 comigrated with 23( S ),25( R ),26‐ trihydroxyvitamin D 3 . This result unequivocally demonstrates that the stereochemistry of the natural 23,25,26‐trihydroxyvitamin D 3 has the 23( S ) and 25( R ) configuration.