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The effect of N ‐methylprotoporphyrin and succinyl‐acetone on the regulation of heme biosynthesis in chicken hepatocytes in culture
Author(s) -
De Matteis Francesco,
Marks Gerald S.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80430-x
Subject(s) - ferrochelatase , heme , protoporphyrin ix , protoporphyrin , biosynthesis , stimulation , chemistry , erythropoietic protoporphyria , acetone , biochemistry , phenobarbital , biology , enzyme , pharmacology , endocrinology , organic chemistry , porphyrin , photodynamic therapy
The essential features of hepatic protoporphyria, namely inhibition of ferrochelatase, accumulation of protoporphyrin and stimulation of 5‐aminolevulinic acid synthase (ALA‐S) were all obtained by treating chicken hepatocytes in culture with small doses of N ‐methylprotoporphyrin. Both N ‐methylprotoporphyrin and succinyl‐acetone, another inhibitor of heme biosynthesis, stimulated ALA‐S when given on their own and also enhanced the stimulation of ALA‐S caused by phenobarbital.