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Catecholamines inhibit insulin‐stimulated glucose transport in adipocytes, in the presence of adenosine deaminase
Author(s) -
Green Allan
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80392-5
Subject(s) - adenosine , adenosine deaminase , medicine , endocrinology , phentolamine , chemistry , insulin , adenosine a1 receptor , propranolol , epinephrine , adenosine receptor , receptor , biology , agonist
Epinephrine, norepinephrine and isoproterenol completely inhibited insulin‐stimulated 2‐deoxyglucose uptake by rat adipocytes, but only when adenosine was prevented from accumulating in the incubation medium by addition of adenosine deaminase. Basal uptake rates were not affected. The effects were not observed in the presence of adenosine dreaminase plus N 6 ‐phenylisopropyl adenosine (a non‐metabolizable adenosine analogue), suggesting that it is the lowered adenosine level rather than the presence of the enzyme itself which allows the catecholamines to inhibit insulin action. The inhibitory effects of the catecholamines were blocked by propranolol but not phentolamine, suggesting that they are mediated via β‐adrenergic receptors.