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Dihydropyridines as potent calcium channel blockers in neuronal cells
Author(s) -
Takahashi Masami,
Ogura Akihiko
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80377-9
Subject(s) - nicardipine , nitrendipine , dihydropyridine , chemistry , p type calcium channel , calcium channel , pheochromocytoma , neurotransmitter , biophysics , neuron , channel blocker , calcium , t type calcium channel , microbiology and biotechnology , endocrinology , biology , biochemistry , neuroscience , receptor , organic chemistry
Nicardipine, one of the dihydropyridine derivatives, in a nanomolar concentration range suppressed the high K + ‐induced neurotransmitter from cultured neuronal cells (chick embryonic neural retina cells and clonal rat pheochromocytoma cells). The high K + ‐induced Ca 2+ uptake into pheochromocytoma cell was also blocked by nicardipine in the same concentration range. [ 3 H]Nitrendipine, another dihydropyridine derivative, bound specifically to pheochromocytoma cell homogenate in a saturable manner. We concluded that dihydropyridines block and bind to the high K + ‐sensitive Ca 2+ channels in neuronal cells.