Premium
Glycosaminoglycan synthesis in skin fibroblasts from patients with osteogenesis imperfecta
Author(s) -
Kapoor R.,
Bourier S.,
Prehm P.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80375-5
Subject(s) - glycosaminoglycan , hyaluronic acid , osteogenesis imperfecta , chondroitin sulphate , chemistry , chondroitin , dermatan sulfate , endocrinology , medicine , fibroblast , biochemistry , chondroitin sulfate , in vitro , anatomy
Glycosaminoglycans were analysed from skin fibroblasts with osteogenesis imperfecta (OI) IIA and IIB. The content of sulphated glycosaminoglycans was greatly increased over age‐matched controls and to a lesser extent with respect to older age control. Dermatan sulphate in comparison with older control was unaltered in the cells of OI IIA and IIB. The concentration of heparan sulphate was higher in the cells than in the medium, whereas hyaluronic acid, chondroitin sulphate and dermatan sulphate content was higher in the medium. The level of hyaluronic acid was greatly elevated in the medium of OI IIB with respect to both controls.