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Antioxidant effect of caeruloplasmin on microsomal lipid peroxidation
Author(s) -
Yamashoji Shiro,
Kajimoto Goro
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80371-8
Subject(s) - ceruloplasmin , lipid peroxidation , microsome , antioxidant , chemistry , biochemistry , microsoma , superoxide , enzyme
Microsomal NADPH‐dependent lipid peroxidation catalyzed by ADP‐Fe 3+ was inhibited by the addition of caeruloplasmin. The antioxidant effect of caeruloplasmin was independent of the superoxide anion (O − 2 scavenging activity. Since caeruloplasmin enhanced the function of ADP‐Fe 3+ acting as electron acceptor for microsomal electron transport system, the antioxidant effect of caeruloplasmin is considered to depend on the ferroxidase activity.