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Vinblastine‐induced autophagocytosis: effects on liver glycogen
Author(s) -
Hirsimäki Pirrko
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80349-4
Subject(s) - vinblastine , glycogen , chemistry , biochemistry , microbiology and biotechnology , biology , chemotherapy , genetics
The possible similarities of the mechanism by which vinblastine induces autophagocytosis in liver were compared with the known effects of glucagon in glucagon‐induced autophagocytosis. A single intraperitoneal injection of vinblastine produced a wave of autophagocytosis in <0.5 h in mouse hepatocytes. Liver glycogen content decreases simultaneously and blood glucose first increased and then decreased below control values. Both liver cAMP concentration and the activity of glycogen phosphorylase remained unchanged. These findings provide evidence tht the induction of autophagocytosis after vinblastine injection is not mediated by cAMP. The increased degradation of glycogen may occur in the lysosomal system by means of increased autophagocytosis.