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Different effects of glucagon and epinephrine on the kinetic properties of liver glycogen synthase
Author(s) -
Bosch Fàtima,
Ciudad Carlos J.,
Guinovart Joan J.
Publication year - 1983
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(83)80346-9
Subject(s) - glucagon , epinephrine , glycogen synthase , glycogen , endocrinology , medicine , chemistry , atp synthase , glycogen phosphorylase , glycogen branching enzyme , hormone , biochemistry , biology , enzyme
Kinetic constants of glygocen synthase ( S 0.5 for glucose‐6‐P and M 0.5 for UDP‐glucose) were determined after hepatocytes isolated from starved rats were incubated with either glucagon or epinephrine. Incubation with these hormones resulted in an increase in both S 0.5 and M 0.5 . However, the action of glucagon resulted in great modifications on S 0.5 whereas epinephrine affected mainly M 0.5 . Therefore, glucagon and epinephrine alter the kinetic properties of glycogen synthase provoke the phosphorylation of glycogen synthase at different site(s) acting through different mechanisms.